Abstract 213: A Comparison of Patient Profiles and 1-year Health Status Outcomes Following a Diagnosis of Peripheral Artery Disease in Two High-income Countries: Insights From the Portrait Registry

Background: Peripheral artery disease (PAD) prevalence is increasing by age in high-income countries. It is unknown whether patient characteristics, treatment profiles, and 1-year PAD-specific health status outcomes differ across health care contexts in high-income countries such as the ones in the United States (US) vs. the Netherlands. Methods: Patients were identified from the Patient-centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease: Investigating Trajectories (PORTRAIT) study which is a prospective, multicenter, international registry of patients presenting to vascular specialty clinics for new onset, or an exacerbation of PAD symptoms. PAD-specific health status was measured by Peripheral Artery Questionnaire (PAQ) at presentation, and at 3, 6 and 12 months follow-up using adjusted generalized repeated measurement models. Results: Out of a total of 1,114 patients,748 patients (67.1%) were from the US and 366 (32.9%) were from the Netherlands. US patients with PAD were significantly older and had a higher cardiovascular risk factor burden including smoking (Table) with more Netherlands patients being referred to supervised vs. unsupervised exercise therapy (SET) as compared with the US cohort after enrollment. US patients presented with significantly lower PAD-specific health status scores (PAQ summary scores) upon presentation (-41.59 vs 49.58, p<0.0001) as well as at 12 months following their vascular work-up (61.05 vs 74.66, p<0.0001). US patients also had lower rates of improvement that consistently lagged behind the Netherlands at all time points (p<0.001). The interaction between country*time was significant at all time points. Conclusion: US patients seeking care for PAD have a different risk profile upon presentation from Dutch patients, including worse health status profiles, and had less exposure to SET. Even after adjustment, worse PAD-specific health status outcomes were seen in the US cohort at baseline throughout 12 months of follow-up. Contrasting risk exposure patterns and health care systems across high-income care settings may highlight mutual learning opportunities to advance the care for PAD.