Electrochemotherapy for a cutaneous squamous cell carcinoma in a Vietnamese pot-bellied Pig (Susscrofa)

Background: With increasing numbers of Vietnamese pot-bellied pigs (Susscrofa) being cared for as pets and increased survival times due to improved husbandry and veterinary care, the possibility of naturally occurring cancer is likely to increase in this species. Case description: A 9-year old, female spayed, Vietnamese pot-bellied pig was presented for evaluation of raised, hemorrhagic crusts, and ulcerated lesions of both flanks, dorsum, ventral abdomen, hind limbs, and caudal ears. The pig's skin was biopsied and histopathology confirmed diffuse squamous cell carcinoma. The pig was treated with eight sessions of electrochemotherapy over the course of one year: 15 IU/m2 of bleomycin intravenously 5 minutes prior to electroporation (series of electrical pulses (1200–1300 V) delivered to the lesions in a grid pattern). The pig tolerated electrochemotherapy without evidence of myelosuppression or substantial gastrointestinal upset and had mild local inflammation/irritation following treatments. At the time of submission, the pig was 18 months post diagnosis and in a sustained partial remission. A new lesion in an untreated location has slowly grown over 2 months. Conclusions and clinical relevance: This is the first report of successful treatment of squamous cell neoplasia in a pot-bellied pig. Cognizance of family pet vs. an animal entering the food chain is important when considering chemotherapy in food producing animals. We received written confirmation from the owner that this pig would not enter the human food supply. Electrochemotherapy is a viable option for cutaneous squamous cell carcinoma in pigs.