Changes in Muscle Strength and Physical Function in Older Patients During and After Hospitalisation: a Prospective Repeated Measures Cohort Study

Aim To investigate changes in knee-extension strength and physical function in older adults during and after acute hospital admission, and the contributions of illness severity, frailty and sedentary activity to changes in knee-extension strength. Methods Prospective repeated-measures cohort study on a sample of participants aged ≥75 recruited within 24 hours of acute hospital admission. Knee-extension, grip strength and functional mobility (de Morton Mobility Index (DEMMI)) were measured at recruitment, day 7 (or discharge if earlier), and at follow-up 4-6 weeks later. During the first 7 days, continuous measurement of physical activity and daily measurements of muscle strength were taken. Participants recalled the functional ability they had 2-weeks before admission and self-reported it at follow-up (Barthel Index). Results Sixty-five of 70 participants (median age 84 years) had at least one repeated measure of muscle strength in hospital. Knee-extension strength declined during hospitalisation by 11% (p < 0.001) but did not change post-hospitalisation (p = 0.458). Grip strength did not change during hospitalisation (p = 0.665) or from discharge to follow-up (p = 0.508). General functional ability (Barthel Index) deteriorated between 2 weeks before admission and follow-up (p < 0.001). Functional mobility (DEMMI) improved during hospitalisation (p < 0.001) but did not change post-hospitalisation (p = 0.508). A repeated-measures mixed model showed that greater loss in knee-extension strength during hospitalisation was associated with increased sedentary time, frailty, and baseline strength, and lower baseline inflammatory levels …