Glucocerebrosidase Mutations and Risk of Parkinson Disease in Chinese Patients

Correspondence: Dr Stüve, Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-9036 (olaf .stuve@utsouthwestern.edu). Author Contributions: Study concept and design: Stüve, Frohman, and Racke. Acquisition of data: Stüve, Cravens, Singh, Frohman, Phillips, Remington, Olek, Monson, and Racke. Analysis and interpretation of data: Stüve, Frohman, Hu, and Hemmer. Drafting of the manuscript: Stüve, Singh, Frohman, Phillips, Remington, Hu, and Hemmer. Critical revision of the manuscript for important intellectual content: Stüve, Cravens, Frohman, Olek, Monson, and Racke. Statistical analysis: Stüve, Cravens, and Hemmer. Obtained funding: Stüve, Frohman, Monson, and Racke. Administrative, technical, and material support: Stüve, Singh, Frohman, Phillips, Remington, Olek, and Racke. Study supervision: Stüve, Frohman, Monson, and Racke. Financial Disclosure: None reported. Although the AFFIRM monotherapy trial and the SENTINEL add-on trial with interferon beta-1a (Avonex) were sponsored by Biogen Idec Inc and Elan Corp, the manufacturers of natalizumab, the work presented in this study was not. Funding/Support: This work was supported in part by a start-up grant from the Dallas VA Research Corporation, a New Investigator Award from VISN 17 in the Department of Veterans Affairs, grant RG3427A8/T from the National Multiple Sclerosis Society (NMSS), and a grant from the Viragh Foundation (O.S.). Support also came from grants NS37513 and NS44250 from the National Institutes of Health and grant RG2969-B-7 from the NMSS (M.K.R.). Additional support came from grants He2386/ 4-1 and He2386/4-2 of the Deutsche Forschungsgemeinschaft (B.H.) and grant NS40993 from the National Institutes of Health (N.L.M.). Additional Contributions: We thank our patients for participating in this study. Brittney Fort, Jane Lee, Janey Phillips, Jill Fowler, Nancy Perna, and Subir Sinha assisted in data acquisition.