Studies on Tissue Residual Level of NeemAzal T / S in Stressed African Catfish ” Clarias gariepinus ” with Reference to the Protective Role of Lupine

The current study aimed to clarify the effects of NeemAzal T/S (NA) on certain blood and tissue (liver and white muscle) oxidative stress parameters in Clarias gariepinus. Tissue residual level of NA (braine, Gills, liver and white muscles) was also monitored. The antioxidant effects of lupin was also studied. Two doses of NeemAzal T/S; 1/10 LC : 5.58 ppm (NA1) and 1/5 LC :11.15 ppm (NA2) and three periods of 10, 20 and 30 days 50 50 were used. The results revealed that NA induced marked hyperglycemia, significant elevations in total peroxide as well as significant decrease of catalase and superoxide dismutase activities in most experimental periods in blood, liver or white muscle. Tissue residues were detected in all studied tissues, either with low or high doses of NA. Sublethal doses of NA led to oxidative damage in liver and white muscle. In turn, administration of lupine could improve the adverse effect induced by NA exposure which might be due to its antihyperglycemic effect as well as its contents of some natural antioxidants.