Knockdown of Ron Kinase Inhibits Mutant PI 3 Kinase and Reduces Metastasis in Human Colon Carcinoma

Jing Wang, Ashwani Rajput, Julie L.C. Kan, Rebecca Rose, Xiao-Qiong Liu, Karen Kuropatwinski, Jennie Hauser, Alexander Beko, Ivan Dominquez, Elizabeth A. Sharratt, Lisa Brattain, Charles LeVea Feng-Lei Sun, David M. Keane, Neil W. Gibson, and Michael G. Brattain From University of Nebraska Medical Center, Eppley Institute for Research in Cancer and Allied Diseases, 987696 Nebraska Medical Center, Omaha, NE 68198 2 Division of Surgical Oncology, Department of Surgery, The University of New Mexico, Albuquerque, NM 87131 Department of Pharmacology and Therapeutics Departent of Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY14263 OSI Pharmaceuticals, Broadhollow Bioscience Park, One Bioscience Park Drive, Farmingdale NY 11735 Running head: Knockdown of Ron kinase leads to reduced metastasis # The first two authors contribute equally to the work. *Corresponding author: University of Nebraska Medical Center, Eppley Institute for Research in Cancer and Allied Diseases, 987696 Nebraska Medical Center, Omaha, NE 68198-7696, Fax: 402-559-3739, Email: jjwang@unmc.edu