Acute Coronary Syndrome Angiotensin-Converting Enzyme Inhibition Is Associated With Reduced Troponin Release in Non – ST-Elevation Acute Coronary Syndromes

OBJECTIVES This study was done to determine the effects of angiotensin-converting enzyme (ACE) inhibition and other clinical factors on troponin release in non-ST-elevation acute coronary syndrome (ACS). BACKGROUND Troponin is now widely used as a marker of risk in ACS, but determinants of its release have not been defined. METHODS This was a prospective cohort study of 301 consecutive patients admitted with non–STelevation ACS. Baseline clinical data were recorded, ACE gene polymorphism was determined and serial blood samples were obtained for troponin-I assay. RESULTS Significant troponin-I release (.0.1 mg/l) was detected in 93 (31%) patients. Pretreatment with ACE inhibitors, recorded in 53 patients (17.6%), independently reduced the odds of troponin-I release (odds ratio 0.25; 95% confidence intervals 0.10 to 0.64) and was associated with lower maximum troponin-I concentrations (median [interquartile range]) compared with patients not pretreated with ACE inhibitors (0.44 mg/l [0.19 to 2.65 mg/l] vs. 4.18 mg/l [0.91 to 12.41 mg/l], p 5 0.01). Pretreatment with aspirin, recorded in 173 patients (57.5%), did not significantly reduce the odds of troponin-I release after adjustment but was associated with lower maximum troponin-I concentrations compared with patients not pretreated with aspirin (2.31 mg/l [0.72 to 8.02 mg/l] vs. 5.85 mg/l [1.19 to 12.79 mg/l], p 5 0.05). The ACE genotyping (n 5 268) showed 81 patients (30%) DD homozygous and 77 (29%) II homozygous. There was no association between ACE genotype and troponin release. CONCLUSIONS We conclude that ACE inhibition reduces troponin release in non-ST-elevation ACS. This is likely to be mediated by the beneficial effects of treatment on vascular reactivity and the coagulation system. (J Am Coll Cardiol 2001;38:724–8) © 2001 by the American College of Cardiology