Pharmacokinetics,Safety and Cognitive Function Profile of Rupatadine 10, 20 and 40 mg in Healthy Japanese Subjects: A RandomisedPlacebo-Controlled Trial

In this randomised, double-blind, placebo-controlled study, 27 male and female healthy Japanese subjects were administered single and multiple escalating rupatadine dose of 10, 20 and 40 mg or placebo. Blood samples were collected at different time points for PK measurements and subjects were assessed for safety and tolerability. The effect of rupatadine on cognitive functioningwas evaluated by means of computerized cognitive tests: rapid visual information processing (RVP), reaction time (RT), spatial workingmemory (SWM) and visual analogue scales (VAS).