Dissecting the role of the myofilament in diaphragm dysfunction during the 1 development of heart failure in mice 2 3 Running header : Influence of heart failure on diaphragmatic myofilament function and composition 4 5

1 Dissecting the role of the myofilament in diaphragm dysfunction during the 1 development of heart failure in mice 2 3 Running header: Influence of heart failure on diaphragmatic myofilament function and composition 4 5 Todd E. Gillis, Jordan M. Klaiman, Andrew Foster, Mathew J. Platt, Jason S. Huber, 6 Melissa Y. Corso and Jeremy A. Simpson 7 8 Department of Integrative Biology, University of Guelph 9 Cardiovasclar Research Center, University of Guelph 10 Department of Human Health and Nutritional Sciences, University of Guelph 11 12 13 *Address correspondence to: 14 Todd E. Gillis, PhD 15 Department of Integrative Biology 16 University of Guelph 17 Guelph, ON, N1G-2W1 18 Canada 19 email: tgillis@uoguelph.ca 20 Tel: 1-519-824-4120 x58786 21 http://comparativephys.ca/gillislab/ 22 23 Articles in PresS. Am J Physiol Heart Circ Physiol (December 23, 2015). doi:10.1152/ajpheart.00773.2015