Plasma CD 163 independently predicts all-cause mortality from HIV-1 infection

Background: CD163, a monocyteand macrophage-specific scavenger receptor, is shed as soluble CD163 (sCD163) during the proinflammatory response. Here, we assessed the association of plasma sCD163 levels in HIV-1 infection to AIDS and all-cause mortality. Methods: Plasma sCD163 levels were measured in 933 HIV-1 infected individuals. Hazard ratios (HR) with 95% confidence intervals (95% CI) associated with mortality were computed by Cox proportional hazards regression. Results: At baseline, 86% were on antiretroviral treatment, 73% had plasma HIV RNA < 50 copies/mL and the median CD4 T cell count was 503 cells/μl. During 10.5 years of follow up there were 167 (17.9%) deaths. Plasma sCD163 was higher in non-survivors than in survivors (4.92 mg/L (3.29-8.65) vs. 3.16 mg/L (2.16-4.64), P=0.0001). The cumulative incidence of death increased with increasing plasma sCD163 levels corresponding to a 6% or 35% increased risk of death for each mg/L or quartile increase in baseline plasma sCD163 (adjusted HR: 1.06 (95% CI: 1.03-1.09) and 1.35 (95% CI: 1.13-1.63), respectively). Conclusion: Plasma sCD163 was an independent marker of all-cause mortality in a cohort of HIV-1 infected individuals suggesting that monocyte/macrophage activation may play a role in HIV pathogenesis and be a target of intervention. by Jles L evin on July 1, 2016 http://jidrdjournals.org/ D ow nladed from