Duplex ultrasonography scanning (ceaduss) – a laboratory model phantom to compare and determine the limitations of enhanced and unenhanced ultrasonography scanning for post-operative surveillance of endovascular abdominal aortic aneurysm repair (evar)

s / International Journal of Surgery 9 (2011) 495–546 497 ABSTRACTS Objective: To determine whether ethnic differences exist in circulating markers of angiogenesis between South Asians, Blacks and Whites. To determine associations between these markers, cardiovascular risk factors and Peripheral arterial disease (PAD). Patients and Methods: We recruited 255 subjects (86 South Asians, 81 Blacks and 79 Whites) between October 2008 and September 2009 attending Sandwell & West Birmingham Hospitals NHS Trust. Subjects were separated into radiologically confirmed symptomatic PAD, risk factor controls (At least 1 cardiovascular risk factor& Ankle Brachial Pressure Index (ABPI)>1) and healthy volunteers (No cardiovascular risk factors& ABPI>1). All subjects completed a questionnaire, anthrompometric measurements and phlebotomy was undertaken. Enzyme linked immunoassay (ELISA) was used to quantify angiogenic markers. Results: Whites had lower angiogenin concentration than both South Asians and Blacks (p1⁄40.0217 and p1⁄40.003 respectively). Angiogenin was higher in diabetics than non-diabetics (p1⁄40.0338). Ang-1 and Ang-2 were correlated with Age (p1⁄40.007 and p1⁄40.006 respectively). Ang-2 was higher in coronary artery disease (p1⁄40.0176) and PAD (p1⁄40.0018). The association between Ang-2 and PAD was apparent in both South Asians (p1⁄40.0084) and Whites (p1⁄40.0484). Conclusions: Ethnic differences in angiogenic markers are evident. This may reflect susceptibility of particular groups to PAD. Of the angiogenic markers, Ang-2 was higher in symptomatic PAD; its levels increasing with advancing disease. SARS Academic and Research Prize 0275 CONTRAST ENHANCED AORTIC DUPLEX ULTRASONOGRAPHY SCANNING (CEADUSS) – A LABORATORY MODEL PHANTOM TO COMPARE AND DETERMINE THE LIMITATIONS OF ENHANCED AND UNENHANCED ULTRASONOGRAPHY SCANNING FOR POST-OPERATIVE SURVEILLANCE OF ENDOVASCULAR ABDOMINAL AORTIC ANEURYSM REPAIR (EVAR) S. Dindyal, A. Sud, M. Brewin, A. Thrush, M. Birch, C. Kyriakides. The Royal London Hospital, Whitechapel, London, UK Objectives: To detect the subgroup of patients whom may require postEVAR intervention, currently all patients undergoing endovascular treatments enter a programme of surveillance, usually with regular CT scan follow-up. We propose ultrasound may be suitable non-invasive follow-up investigation and we aimed to determine the absolute limitations of ultrasound in detecting low flow endoleaks and compare the effects of the addition of microbubble contrast enhancement. Methods: We constructed an EVAR-simulation-phantom with endoleak represented by a smaller lumen with variable flow alongside the fixed stent. Distances between the two vessels was varied by viewing from set stent positions and flows were viewed from anterior, posterior or lateral. Subjects consisted of ultrasonographers, who examining the phantoms geometric parameters with colour doppler then repeated using CEADUSS. Results: Anterior endoleaks were detected more frequently than lateral then posterior positioned leaks were the most difficult to detect. The addition of contrast improved anterior leak detection from 76.4% to 98.6% (P<0.001) and also lateral endoleaks from 59.7% to 77.8% (P<0.05). However, posterior endoleak detection was not significantly improved (62.5% to 61.1%). Conclusion: We have demonstrated that endoleak certainity is improved significantly by using microbubble contrast enhancement and should be considered a adjunct for routine EVAR surveillance. SARS Academic and Research Prize 0277 SMA – A NEW PROGNOSTIC MARKER IN ORAL CANCERS Dan Marsh , Kerry Chester , Gareth Thomas . 1 Lister Hospital, Stevenage, UK; 1 Southampton Medical School, Southampton, UK; UCL Cancer Institute,