Canine parvovirus vaccination and immunisation failures: are we far from disease eradication?

•Despite extensive vaccination, canine parvovirus (CPV) still represents one of the major causes of pups’ mortality.•CPV immunisation failures occur frequently and recognize different reasons.•Interference by maternally-derived antibodies is the main cause of CPV immunisation failures.•Eradication of CPV infection is a challenge for the future, but it will not be achieved in a short time