aytime Prazosin Reduces Psychological Distress to rauma Specific Cues in Civilian Trauma Posttraumatic tress Disorder letcher

ackground: Persons with posttraumatic stress disorder (PTSD) whose trauma-related nightmares improve or resolve with bedtime dministration of the alpha-1 adrenergic antagonist prazosin often continue to experience PTSD symptoms during the day. This study ddressed whether daytime prazosin compared to placebo would alleviate psychological distress provoked experimentally by a rauma-related word list included in the emotional Stroop (E-Stroop) paradigm. ethods: Eleven persons with civilian trauma PTSD who continued to experience daytime PTSD symptoms despite a stable bedtime razosin dose that suppressed trauma-related nightmares were studied. Prazosin and placebo were administered on two different ccasions in the early afternoon followed two hours later by the E-Stroop. Effects of drug on psychological distress were assessed by the rofile of Mood States (POMS). esults: POMS total score and an “emotional distress” POMS subscale score following trauma-related words were significantly lower n the prazosin than placebo condition. There were no treatment effects on E-Stroop completion time. In 10 subjects who continued pen label daytime prazosin, there was a reduction in global PTSD illness severity at 2-week follow-up. onclusions: Daytime prazosin pretreatment reduced psychological distress specifically to trauma cues. Adding daytime prazosin to edtime prazosin may further reduce overall PTSD illness severity and distress.