jmbReview Gold Nanoparticles Conjugation Enhances Antiacanthamoebic Properties of Nystatin , Fluconazole and Amphotericin B

Nanomedicine has recently emerged as a viable alternative to organic drugs especially in the improvement of new and more efficacious antimicrobials [1, 2]. Due to a continuous lack in-drug approvals, and ever-growing resistance of microbes against common antimicrobial drugs, nanoconjugates are anticipated as the next generation of antimicrobial agents [3]. Nanoparticles are effective drug delivery agents and can increase the bioavailability of drugs at target sites. Due to their small size, they can be loaded with a high amount of drug molecules, thus reducing the risks of toxicity and side effects. Numerous metallic and metal oxide nanoparticles now being utilized in biomedicines have been developed with copper, silver, gold, platinum, iron oxide, zinc oxide, etc. These nanoparticles have shown tremendous diagnostic and therapeutic potential against cancer, conditions of the central nervous system, and infectious disease. The most common examples of nanoparticles used against infectious diseases are of silver Received: May 17, 2018 Revised: October 29, 2018 Accepted: November 1, 2018