A Dual-Modal Therapeutic Role of Lactate Oxidase-Embedded Hierarchical Porous Zeolitic Imidazolate Framework as Nanocatalyst for Effective Tumor Suppression.

The increasing evidences support the fact that lactate in tumor microenvironment (TME) plays a vital role in tumor proliferation, metastasis and recurrence, which in turn is emerging as one of the most interesting molecular targets for tumor treatment. Here, hierarchical porous zeolitic imidazolate framework-8 (ZIF-8) as the nanocarrier is fabricated to simultaneously load lactate oxidase (LOD) and Fe3O4 NPs, called LOD& Fe3O4@ZIF-8 NPs (LFZ NPs) for tumor therapy. On one hand, the sharp consumption of lactate in TME by LOD will change the essential "soil" where tumor cells live so as to suppress tumor rapid growth. One the other hand, hydrogen peroxide (H2O2) is produced in TME from the oxidation of lactate catalyzed by LOD and subsequently converted to highly toxic hydroxyl radicals (•OH) catalyzed by Fe3O4 NPs via Fenton-like reactions to kill tumor cells. Based on the endogenous catalysis, this dual-modal strategy of tumor therapy based on lactate is simple, safe and effective, which deserves to be well concerned.