Relationship Between Themonocyte Chemo-Attractant Protein-1gene Rs1024611 A>G Polymorphism And Cancer Susceptibility: A Meta-Analysis Involving 14,617 Subjects

Background Inflammatory and inducible chemokines are the hallmarks of malignancy. Monocyte chemo-attractant protein-1 (MCP-1) is a crucial chemokine implicated in infection and inflammation.Methods: We performed an updated meta-analysis of thirty independent case-control studies with 6,777 cancer cases and 7,840 controls to determine if theMCP-1gene rs1024611 A > G variant is associated with the risk of cancer.Results: The G allele carriers of rs1024611 in theMCP-1gene might have a null association with cancer risk in overall comparison. In a subgroup analysis by ethnicity, we identified a marked association between theMCP-1 G allele rs1024611 polymorphism and cancer risk in the Caucasian populations (GGvs. AA: OR = 1.72, 95% CI, 1.12-2.64,P= .013, and GGvs. AG/AA: OR = 1.82, 95% CI, 1.19-2.78,P= .006). The potential bias in literature selection was witnessed in this meta-analysis (Gvs. A:P (Begg's) = 0.187,P-Egger's = 0.049; and GG/GAvs. AA:P (Begg's) = 0.069,P-Egger's = 0.024). The adjusted ORs and CIs of the nonparametric "trim-and-fill" method demonstrated the reliability of these findings. The outcome of heterogeneity analysis indicated that heterogeneity might be due to small sample sizes (<1000 subjects), cancer types (bladder cancer, other cancers), ethnicity (Asians), and population-based studies. However, the sensitivity analysis validated the reliability of the findings.Conclusion: In conclusion, this updated meta-analysis showed that the G carrier of theMCP-1gene rs1024611 is associated with susceptibility to cancer in Caucasian.