Program and Abstracts Thirty-first Annual Meeting of the Surgical Infection Society Palm Beach, Florida May 11–14, 2011

Yan T Ortiz-Pomales, Luis G Reys, Gerald A Cheadle,Michael J Krzyzaniak,Nicole E Lopez,Ann-Marie Hageny,Brian Eliceiri,Andrew Baird,Vishal Bansal,Raul Coimbra,Robert Kraft,David N Herndon,Ludwik Branski,Celeste C Finnerty,Marc G Jeschke,Lemeng Zhang,Pinhua Pan,Jon Cardinal,Gary Nace,John Evankovich,Timothy Billiar,Allan Tsung, Lisa Flynn,Lisa Hall Zimmerman, Alexander Rose,Jing Zhao, Krista Wahby, Bryan Dotson,Robert Wilson, Steven Tennenberg, Gregory Tiesi,Diego Reino,Dave Palange, Qi Lu, Leonard Mason,Sharvil Sheth, Jacquelyn Tomaio,Nick Arora,Edwin Deitch,Amani D Politano,Tjasa Hranjec,Laura H Rosenberger, Kristin T Campbell, Lin M Riccio,George J Stukenborg,Robert G Sawyer, Carlos A Tache-Leon, Alexander V Zaborin, Christopher Holbrook,Donald Liu,Olga Y Zaborina,John C Alverdy,Daithi S Heffernan,Sean F Monaghan,Zach Gregg,Michael D Connolly,Shea Gregg,Charles A Adams,William G Cioffi,Claudia N Emami, Rahul Mittal,Henri R Ford,Nemani V Prasadarao, Ibrahim Yazji,Sodhi Chhinder,Matthew Neal,Thomas Prindle,Maria Branca,Anthony Russo, Congrong Ma, Christopher Vos,David J Hackam, Sangyang Jia, Song H Jia, Emmanuel Charbonney, Zeenat Malam, Jean Parodo,John C Marshall, Richard J Isaacs, Kenneth A Debelak,Patrick R Norris,Judith M Jenkins, Jeffery C Rooks,Matthew J Eckert,Addison K May, Erik M Boczko, Youmna E Abi-Haidar,Kalpana Gupta,Judith Strymish, Sandra Williams,Kamal MF Itani, Gina Howell, Lanping Guo,Xianghong Zhang, Richard D College, Matthew R Rogengart, Mark Diebel, David M Liberati,Lawrence N Diebel, Ryan K Nelson,Valeriy Poroyko,John C Alverdy, Michael J Morowitz, Charles E Hobson, Meghan Brennan, Shahab Bozorgmehri,Philip A Efron,Azra Bihorac, Holly K Sheldon, Joanna Ng, Gustavo Bauza, Juan Mella, Melanie L Gainsbury, Suresh Agarwal, Peter Burke, Tjasa Hranjec,Brian R Swenson,Laura H Rosenberger, Amani D Politano, Lin M Riccio, Rosemarie Metzger, Kimberly A Popovsky,Addison K May, Robert G Sawyer, David M Hill, Thomas J Schroeppel, Louis J Magnotti, Lesley P Clement, Peter E Fischer, Timothy C Fabian, Martin A Croce, Matthew C Byrnes, Eric Irwin, Patty Reicks, Gregory J Beilman, Gerard P De Castro, Grant V Bochicchio, Ian R Driscoll, Deborah M Stein, Kelly M Bochicchio, Shijun Zhu, Manjari Joshi, John R Hess, Thomas M Scalea, Emmanuel Charbonney, Yangmei Li,David Klein, Alexander Romaschin,Avery B Nathens,John C Marshall

Surgical Infections（2011）

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摘要

Background: Trauma/Hemorrhagic shock (T/HS) induced gut injury is known to initiate a dysfunctional inflammatory response leading to secondary lung injury. Our group has shown that vagal nerve stimulation (VNS) protects the intestinal epithelial integrity, attenuates inflammatory cytokine formation, and protects the lung after a thermal insult. We hypothesize that VNS will protect the lung from injury following trauma/hemorrhagic shock.Methods: Male Balb/c mice were subjected to a trauma/hemorrhagic shock model (mean arterial pressure of 35 mmHg for one hour), with and without right cervical vagal nerve stimulation. A cohort of animals underwent abdominal vagotomy (Vx) at the gastro-esophageal junction prior to vagal nerve stimulation and trauma/hemorrhagic shock. Lung histology (H&E), myeloperoxidase (MPO) and ICAM-1 immuno-staining, and MPO enzymatic assay were analyzed 24 hours post-shock …

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