No effects on appetite or body weight in weight-reduced individuals of foods containing components previously shown to reduce appetite - results from the SATIN (Satiety Innovation) study

Abstract Aims The aim was to investigate the acute and sustained effects of foods previously shown to reduce appetite on appetite and weight loss maintenance. Methods Following an 8-week weight loss phase achieving ≥8 % weight loss and 7-10 days of weight-stabilization, participants underwent a double-blinded, randomized, parallel 12-week weight loss maintenance period with either one of three intervention products previously shown to reduce appetite or matching controls. Appetite probe days were completed at baseline, at the start of the weight loss maintenance (acute effects), and after the weight loss maintenance (sustained effects) along with body weight measurements. Results In total, 197 participants entered the weight loss maintenance period and were included in intention-to-treat analyses. No differences in acute or sustained effects on appetite were observed between the intervention and control groups for any of the three products (24-h energy intake: all P≥0.63; overall appetite suppression score assessed by visual analogue scales: all P≥0.14). Also, no difference in body weight was observed (all P≥0.62). Conclusions Exposure to specific foods previously shown to reduce appetite was not found to reduce appetite acute or sustained or to improve weight loss maintenance as compared to control products in weight-reduced individuals.