Improving dynamic contrast-enhanced MRI of the lung using motion-weighted sparse reconstruction: Initial experiences in patients.

PURPOSE:The purpose of this study was to evaluate the performance of motion-weighted Golden-angle RAdial Sparse Parallel MRI (motion-weighted GRASP) for free-breathing dynamic contrast-enhanced MRI (DCE-MRI) of the lung. METHODS:Motion-weighted GRASP incorporates a soft-gating motion compensation algorithm into standard GRASP reconstruction, so that motion-corrupted motion k-space (e.g., k-space acquired in inspiratory phases) contributes less to the final reconstructed images. Lung MR data from 20 patients (mean age = 57.9 ± 13.5) with known pulmonary lesions were retrospectively collected for this study. Each subject underwent a free-breathing DCE-MR scan using a fat-statured T1-weighted stack-of-stars golden-angle radial sequence and a post-contrast breath-hold MR scan using a Cartesian volumetric-interpolated imaging sequence (BH-VIBE). Each radial dataset was reconstructed using GRASP without motion compensation and motion-weighted GRASP. All MR images were visually evaluated by two experienced radiologists blinded to reconstruction and acquisition schemes independently. In addition, the influence of motion-weighted reconstruction on dynamic contrast-enhancement patterns was also investigated. RESULTS:For image quality assessment, motion-weighted GRASP received significantly higher visual scores than GRASP (P < 0.05) for overall image quality (3.68 vs. 3.39), lesion conspicuity (3.54 vs. 3.18) and overall artifact level (3.53 vs. 3.15). There was no significant difference (P > 0.05) between the breath-hold BH-VIBE and motion-weighted GRASP images. For assessment of temporal fidelity, motion-weighted GRASP maintained a good agreement with respect to GRASP. CONCLUSION:Motion-weighted GRASP achieved better reconstruction performance in free-breathing DCE-MRI of the lung compared to standard GRASP, and it may enable improved assessment of pulmonary lesions.