3D Printed Scaffolds for Cancer Precision Medicine.

Tissue engineering. Part A(2020)

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摘要
Three-dimensional (3D) engineered systems have been widely investigated as drug delivery systems (DDS) or cancer models with the aim to develop effective cancer therapies. The in vitro and in vivo models developed via 3D printing (3DP) and tissue engineering concepts have significantly contributed to our understanding of cell-cell and cell-extracellular matrix interactions in the cancer microenvironment. Moreover, 3D tumor models were used to study the therapeutic efficiency of anticancer drugs. The present study aims to provide an overview of applying the 3DP and tissue engineering concepts for cancer studies with suggestions for future research directions. The 3DP technologies being used for the fabrication of personalized DDS have been highlighted and the potential technical approaches and challenges associated with fused deposition modeling, the inkjet-powder bed and stereolithography as the most promising 3DP techniques for drug delivery purposes are briefly described. Then, the advances, challenges and future perspectives in tissue-engineered cancer models for precision medicine are discussed. Overall, future advances in this arena depend on the continuous integration of knowledge from cancer biology, biofabrication techniques, multi-omics and patient data, and medical needs to develop effective treatments ultimately leading to improved clinical outcomes.
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