Alpha 1-Acid Glycoprotein And Seminal Parameter In Chronic Hemodialysis Patients

Introduction: To find out the changes in seminal quality of hemodialysis chronic renal patients, we investigated the possible relationship between seminal parameter and seminal alpha 1-acid glycoprotein levels in chronic hemodialysis patients. Methods: Prospective study of prevalence realized in the Hemodialysis Sector of the University Hospital of the University of Brasilia, between July 2016 and December 2016. Men aged 18-60 years grouped into case groups (n = 81) represented by chronic hemodialysis patients and control group (n = 20) of healthy men without clinical or laboratory signs of infection and eugonadic. We performed a spermogram, hormonal profile, and assessment of leukocytes and seminal alpha 1-acid glycoprotein level in the semen. The most appropriate statistical test was applied to verify differences and correlations between the studied variables. Results: The age in case and control is similar (49.47 +/- 5.55 years vs 50.53 +/- 4.24 years; p = 0.060). Mean level of alpha 1-acid glycoprotein in human seminal plasma were not significantly different between case and control (48.52 +/- 4.90 mg/L vs 46.33 +/- 4.29 mg/L; p = 0.10) and between normosperm and oligosperm (47.76 +/- 5.15 mg/L vs 49.48 +/- 4.49 mg/L; p = 0.19). Mean level of alpha 1-acid glycoprotein in human seminal plasma in the case group, which were classified into severe, moderate, mild, and normosperm, were similar to each other (p = 0.27) and did not correlate (p > 0.05) with the analyzed seminal parameters. All participants presented normal hormonal profile. Conclusion: Results of this study suggest that the seminal alpha 1-acid glycoprotein levels do not help in the initial evaluation of patients with seminal parameter changes.