A simple phototheranostics strategy to continuously deliver singlet oxygen in dark and hypoxic tumor microenvironment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2020)
摘要
Continuous irradiation during photodynamic therapy (PDT) inevitably induces tumor hypoxia, thereby weakening the PDT effect. In PDT-induced hypoxia, providing singlet oxygen from stored chemical energy may enhance the cell-killing effect and boost the therapeutic effect. Herein, we present a phototheranostic (DPPTPE@PEG-Py NPs) prepared by using a 2-pyridone-based diblock polymer (PEG-Py) to encapsulate a semiconducting, heavy-atom-free pyrrolopyrrolidone-tetraphenylethylene (DPPTPE) with high singlet-oxygen-generation ability both in dichloromethane and water. The PEG-Py can trap the O-1(2) generated from DPPTPE under laser irradiation and form a stable intermediate of endoperoxide, which can then release O-1(2) in the dark, hypoxic tumor microenvironment. Furthermore, fluorescence-imaging-guided phototherapy demonstrates that this phototheranostic could completely inhibit tumor growth with the help of laser irradiation.
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关键词
fluorescence,imaging agents,nanoparticles,photothermal therapy,theranostics
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