Emerging role of angiotensin AT2 receptor in anti-inflammation: an update.

The hyperactive RAS and inflammation are closely associated. The angiotensin-IUAT(1)R axis of the RAS has been explored extensively for its role in inflammation and a plethora of pathological conditions. Understanding the role of AT(2)R in inflammation is an emerging area of research. The AT(2)R is expressed on a variety of immune and non-immune cells, which upon activation triggers the release of a host of cytokines and has multiple effects that coalesce to anti-inflammation and prevents maladaptive repair. The anti-inflammatory outcomes of AT(2)R activation are linked to its well-established signaling pathways involving formation of nitric oxide and activation of phosphatases. Collectively, these effects promote cell survival and tissue function. The consideration of AT(2)R as a therapeutic target requires further investigations.