P2.16-39 The Association Between Dietary Protein Intake and the Risk of Lung Cancer: A Meta-Analysis

Dietary protein intake had been explored whether had some effective on lung cancer risk, however, the results were not consistent. This meta-analysis aimed to find exact relationship between them. Databases of PubMed, Embase, and Web of Science were retrieved up to January 1, 2019. Summarized odds ratio (OR) with corresponding 95% confidence intervals (CI) were calculated. Publication bias and sensitivity analysis were assessed. Seven articles with 8 independently studies (4 population-based case-control studies (PBCC) and 4 hospital-based case-control studies (HBCC)) involving 2990 cases and 7142 participants were used in this paper. The overall analysis suggested that dietary protein intake had no significant association on lung cancer risk (Summarized OR= 0.951, 95%CI= 0.798-1.134, I2= 53.0%, P for heterogeneity= 0.037). However, when we explored the association between lung cancer risk and geographic location, we found an inverse association among Asian populations (Summarized OR= 0.880, 95%CI= 0.840-0.922), instead of North American populations or European populations. Findings from this meta-analysis indicated that higher intake of protein may be associated with decreased of lung cancer risk among Asian populations, instead of other populations. As some limitations listed in our study, more studies are warranted to further confirm the association between them.