A Nanozyme-Based Bandage with Single-Atom Catalysis for Brain Trauma.
ACS nano(2019)
摘要
Neurotrauma is one of the most serious traumatic injuries, which can induce an excessive amount of reactive oxygen and nitrogen species (RONS) around wound, triggering a series of biochemical responses and neuroinflammation. Traditional antioxidant-based bandage can effectively decrease infection via preventing oxidative stress, but its effectiveness is limited to a short period of time due to the rapid loss of electron-donating ability. Herein, we developed a nanozyme-based bandage using single-atom Pt/CeO2 with a persistent catalytic activity for non-invasive treatment of neurotrauma. Single-atom Pt induced the lattice expansion and preferred distribution on (111) facets of CeO2, enormously increasing the endogenous catalytic activity. Pt/CeO2 showed a 2-10 times higher scavenging activity against RONS as well as 3-10 times higher multi-enzyme activities than CeO2 clusters. The single-atom Pt/CeO2 retained the long-lasting catalytic activity for up to a month without obvious decay due to enhanced electron donation through the Mars-van Krevelen reaction. In vivo studies disclosed that the nanozyme-based bandage at the single-atom level can significantly improve the wound healing of neurotrauma and reduce neuroinflammation.
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关键词
nanozyme,single-atom catalysis,brain trauma,wound repair,noninvasive therapy
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