Distortion correction for high-resolution single-shot EPI DTI using a modified field-mapping method.

Purpose The widely used single-shot EPI (SS-EPI) diffusion tensor imaging (DTI) suffers from strong image distortion due to B-0 inhomogeneity, especially for high-resolution imaging. Traditional methods such as the field-mapping method and the top-up method have various deficiencies in high-resolution SS-EPI DTI distortion correction. This study aims to propose a robust distortion correction approach, which combines the advantages of traditional methods and overcomes their deficiencies, for high-resolution SS-EPI DTI. Methods The proposed correction method is based on the echo planar spectroscopic imaging field-mapping followed by an intensity correction procedure. To evaluate the efficacy of distortion correction, the proposed method was compared with the conventional field-mapping method and the top-up method, using a newly developed quantitative evaluation framework. The correction results were also compared with multi-shot EPI DTI to investigate whether the proposed method can provide high-resolution SS-EPI DTI with high geometric fidelity and high time efficiency. Results The results show that accurate field-mapping and intensity correction are critical to distortion correction in high-resolution SS-EPI DTI. The proposed method can provide more precise field maps and better correction results than the other two methods (p < 0.0001), and the corrected images show higher geometric fidelity than those from MS-EPI DTI. Conclusion An effective method is proposed to reduce image distortion in high-resolution SS-EPI DTI. It is practical to achieve high-resolution DTI with high time efficiency and high structure accuracy using this method.