Study the Correlation of Helicobacter Pylori Infection with Bronchial Asthma and Its Relation to Asthma Severity

Background: Helicobacter pylori (HP) infection was linked with allergic diseases and asthma. However some studies reported contradictory results. Aim of the study: Evaluation the Role of Helicobacter pylori infection in asthmatic patients and its Relation to Asthma Severity. Patients and methods: the current work included 120 patients with Bronchial Asthma and 60 healthy persons as control. All were submitted to history taking, clinical examinations, laboratory and radiological investigations. HP was diagnosed by antigen detection in stool. Results: HP was reported in 36 patients with bronchial asthma (30.0%) and 25 healthy subjects (41.7%) with non-significant difference between both groups. asthmatic patients with positive HP infection revealed good pulmonary function tests, lower IgE antibodies, and significantly higher antibodies titer against HP. In addition, H-pylori infection was significantly prevalent with mild asthma (66.7%), then moderate (30.6%) and finally severe asthma (2.8%). The Serum level of HP antibody titer was inversely correlated with FEV1/FVC and IgE. Positively correlated with pre FEV1. Thus, we could say that, asthma severity is inversely correlated with H-pylori infection. Conclusion: Asthma severity was negatively correlated with HP infection, patients with Bronchial Asthma and HP infection revealed good pulmonary function tests and lower IgE antibodies that favor the protective role of HP infection in those patients.