Optimized Cellulose Nanocrystal Organocatalysts Outperform Silica-Supported Analogues: Cooperativity, Selectivity, and Bifunctionality in Acid–Base Aldol Condensation Reactions

Cellulose nanocrystals (CNCs) are demonstrated as effective, ordered supports for cooperative acid–base heterogeneous organocatalysis, offering an alternative to typical silica supports. CNC catalyst surface chemistry is optimized through quantitative control of the loadings of carboxylic acids, primary amines, and sulfate half-esters, as characterized by elemental analysis, conductometric titration, and FT–IR spectroscopy. Catalysts are evaluated in the liquid phase aldol condensation of 4-nitrobenzaldehyde or furfural with acetone. Carboxylic acids are effective cooperative acid partners in CNC organocatalysts, and site-specific activity is strongly correlated with the COOH:NH2 ratio. Partial sulfate half-ester removal, high acid/base ratios, and use of unprotected diamines in the catalyst synthesis lead to optimized CNC catalyst function (site-time yield = 1.0 × 10–4 s–1). High selectivities to dehydrated aldol products (u003e80%) are achieved due to the acid content of the CNC catalysts. CNC catalysts out...