FRI0066 Impact of serum adipokines in early stages of rheumatoid arthritis

Background Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease. Adipose tissue is regarded as an active endocrine organ producing adipokines such as leptin and adiponectin, and some proinflammatory cytokines which have proinflammatory properties that account for chronic low-grade systemic inflammation Objectives To investigate the levels of adipokines in eRA and establish their association with the state of rheumatic condition Methods Cross sectional study was conducted. 51 patients with eRA according to the ACR/EULAR 2010 criteria and 51 healthy controls matched by age and gender, were included. A complete medical history was obtained. Adiponectin levels measured by Luminex technology, IL6 by chemiluminescence and lptin by Enzyme-linked immunosorbent assay. Serum markers of RA such as rheumatoid factor, erythrocyte sedimentation rate(ESR), C reactive protein(CRP), and anticitrullinated protein antibodies-APCA IgG/IgA. Disease activity was evaluated by DAS28CRP, DAS28ESR, CDAI, SDAI and RAPID3, the functional status using Multidimensional health assessment questionnaire(MDHAQ) and radiological status by Simple Erosion Narrowing Score(SENS). An association analysis was made to evaluate the relationship between adipokines levels and rheumatologic conditions using X2 test, Mann Whitney and logistic regression model was performed to confirm this associations. All the results were performed with a level of significance of 95% Results In the eRA group, 80.39% were women, the mean age was 48.54±10.93 years. 37.25% had overweight and 13.72% had obesity Among the controls, 80.39% were women, with the mean age of 48.55±11.07 years. 27.45% had overweight and 5.88% had obesity.45,09% moderate activity and 17.64% high activity by DAS28ESR. High leptin levels were found in 64.7% vs 23.5% in healthy controls (p=0,001). High adiponectin levels was found associated to BMI 25(p=0.038) and disease activity by RAPID3(p=0.039). The presence of joint space narrowing in hands was associated with low adiponectin levels(p=0.044). The association of leptin levels>1.67 ng/mL with the diagnosis of RA was maintained in the model adjusted for the presence of P gingivalis, DAS28-ESR, CRP >3 mg/L, economic status and BMI>30, OR=2.79 95% CI (1.54–5.07). The presence of high leptin and IL6 levels and low level adiponectin at the same time were more frequently found in the female gender(p=0.047), primary schooling(p=0.050), BMI>30(p=0.023), patients with radiological damage SENS>3 (p=0.047) and were found associated at the same time to MDHAQ>3, BMI>25 and RAPID3 >12 (OR 5.03 95% CI 1.05–24) adjusted to clinical variables Conclusions The role of adipokines as the leptin could be considered to be the bridge between immune tolerance, metabolic function and autoimmunity and suggests the possibility to use circulating levels of adipokines as potential biomarkers of disease activity and functional status in early stage of rheumatoid arthritis Reference [1] Senolt L. Expert Rev Clin Immunol2017;13:1–3. Disclosure of Interest None declared