SAT0328 Big-Five Personality in Sjogren Syndrome – Association with ESSPRI

Background The severity of symptoms of dryness, pain and fatigue may be determined by psychological features patients with Sjogren9s syndrome (SS). The Big-Five framework is a widely examined model which represent personality at the broadest level of abstraction. The NEO Personality Inventory-Revisited (NEO-PI-R) is frequently used questionnaire to assess the Big-Five domains: Neuroticism ( N ), Extraversion ( E ), Openness to Experience ( O ), Agreeablenes ( A ) and Conscientiousness ( C ). Objectives To Big-Five analyse of personality of SS patients and association with the severity of dryness, pain and fatigue measured by ESSPRI (EULAR SS Patient Reported Index). Methods One hundred and five patients with confirmed SS by AECG criteria (mean age 51,34 years, mean disease duration 5,98 years) and fifty-four healthy controls (mean age 51,35 years) participated in study. All participants were females and provided written informed consent. The diseasy activity was measured by ESSDAI (EULAR SS disease activity index) and ESSPRI. All participants filled out the sociodemographic questionnaire (age, educational level, work and marital status, residence, social support and comorbidity). The Big-Five personality traits were measured using NEO-P-R. The 240 items are answered on a 5-point Likert scale ranging from strongly disagree to strongly agree. The analysis was performed using the SPSS program (version 16.0). Data were examined by independent t -test, Chi-square test and Mann-Whitney test. The association of the Big Five personality traits with the ESSPRI was examined using linear regression analyses. A p-value Results Statistical significant differences between two groups were observed in educational level (p=0.001), work status (p=0.001), residence (p=0.001) and social support (p=0.05), but they did not different in age, marital status and comorbidity (pu003e0.05). In SS patients, the median of ESSDAI was 6 (range 4–11), the median ESSPRI was 5.33 (range 3.66–6.66). Compared to healthy controls, SS patients showed significatly higher scores in N (94.76 vs. 84.63, p=0.006) and lower E (94.79 vs.104.20, p=0.002) and O (101.86 vs. 111.17, p=0.05) domens. Scores A and C were similare in groups (120.48 vs 121.04 and 122.97 vs. 125.02, pu003e0.05). Futher, E and O domens were significantly associated with ESSPRI (p=0.008, p=0.000), while N was borderline (p=0.056). After adjustment for confounding variables, only E domen remained significantly associated with ESSPRI (p=0.01). The analyse showed that E domen was negatively associated with age (B= -0.341, p=0.013), unmarital status (B= -4.317, p=0.013) and positive associated with social support (B=7.952, p=0.013). Conclusions Patients with SS had a higher levels of Neuroticism and lower levels of Extraversion and Opennes to experiences compared to healthy persons. In SS patients, Extraversion and Openness were associated with severity of symptoms of dryness, pain and fatigue. The social support is significantly associated with higher level Extraversion, in contrast to older and single individuals. Disclosure of Interest None declared