Abstract 11909: Migraine Headaches and Cardiovascular Outcomes in Women With Symptoms and Signs of Ischemic Heart Disease: Results of an Extended follow-up From the Women’s Ischemia Syndrome Evaluation

Introduction: Data regarding the association between migraine headaches (MH) and cardiovascular (CV) events in women have been inconsistent. The aim of this study was to determine the long-term risk of CV events among women with and without MH who were evaluated for suspected ischemic heart disease (IHD) in the Women’s Ischemia Syndrome Evaluation (WISE) Study. Methods: Women reporting a history of MH were identified from the WISE cohort. Extended follow-up data were available for a median follow-up of 6 years. Cox proportional adjusted hazard ratios (HR) were constructed for time to first adverse CV event (CV death, non-fatal myocardial infarction [MI], heart failure hospitalization, or non-fatal stroke) among women with and without MH. Additionally, HR were determined for each event separately, as well as, all-cause death, angina hospitalization, death or MI, and CV death or MI. Results: Data on self reported MH were available on 917 women. A total of 224 (24.4%) reported a history of MH. Compared to those who did not report a history of migraines, women with a history of MH had an increased adjusted* risk of CV events (HR 1.83 CI 1.22-2.75, p=0.004) at a median follow up of 6-years. This result was mainly due to an increase in the risk of stroke (HR 2.33 CI 1.16-4.68, p=0.018) (Table 1). Conclusion: Among women being evaluated for IHD, those who reported a history of MH had an increased risk of future CV event. This finding was primarily driven by the more than 2-fold increased risk of stroke. ![][1] [1]: /embed/graphic-1.gif