Asymmetric total synthesis of cryptoconcatone I
Organic & Biomolecular Chemistry(2019)
摘要
Asymmetric total synthesis of the naturally occurring cryptoconcatone I, which possesses a -Z-butenolide framework, is described here for the first time. Asymmetric propargylation, E-selective cross metathesis, and regioselective reductive epoxide ring opening were employed to access the enantiopure terminal alkyne. Late stage bimetallic cascade cyclization of the alkyne with (Z)-3-bromoacrylic acid afforded the natural product in an efficient way.
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