Electrostatic Switching and Selection of H 3 O + , NO + , and O 2 +• Reagent Ions for Selected Ion Flow-Drift Tube Mass Spectrometric Analyses of Air and Breath.

Soft chemical ionization mass spectrometry techniques, particularly the well-established proton transfer reaction mass spectrometry, PTR-MS, and selected ion flow tube mass spectrometry, SIFT-MS, are widely used for real-time quantification of volatile organic compounds in ambient air and exhaled breath with applications ranging from environmental science to medicine. The most common reagent ions H3O+, NO+, or O-2(+center dot) can be selected either by quadrupole mass filtering from a discharge ion source, which is relatively inefficient, or by switching the gas/vapor in the ion source, which is relatively slow. The chosen reagent ions are introduced into a flow tube or flow-drift tube reactor where they react with analyte molecules in sample gas. This article describes a new electrostatic reagent ion switching, ERIS, technique by which H3O+, NO+, and O-2(+center dot) reagent ions, produced simultaneously in three separate gas discharges, can be purified in post-discharge source drift tubes, switched rapidly, and selected for transport into a flow-drift tube reactor. The construction of the device and the ion molecule chemistry exploited to purify the individual reagent ions are described. The speed and sensitivity of ERIS coupled to a selected ion flow drift tube mass spectrometry, SIFDT-MS, is demonstrated by the simultaneous quantification of methanol with H3O+, acetone with NO+, and dimethyl sulfide with O-2(+center dot) reagent ions in single breath exhalations. The present ERIS approach is shown to be preferable to the previously used quadrupole filtering, as it increases analytical sensitivity of the SIFDT-MS instrument while reducing its size and the required number of vacuum pumps.