Endurance Training with or without Glucose-Fructose Ingestion: Effects on Lactate Metabolism Assessed in a Randomized Clinical Trial on Sedentary Men

Glucose-fructose ingestion increases glucose and lactate oxidation during exercise. We hypothesized that training with glucose-fructose would induce key adaptations in lactate metabolism. Two groups of eight sedentary males were endurance-trained for three weeks while ingesting either glucose-fructose (GF) or water (C). Effects of glucose-fructose on lactate appearance, oxidation, and clearance were measured at rest and during exercise, pre-training, and post-training. Pre-training, resting lactate appearance was 3.6 +/- 0.5 vs. 3.6 +/- 0.4 mg.kg(-1).min(-1) in GF and C, and was increased to 11.2 +/- 1.4 vs. 8.8 +/- 0.7 mg.kg(-1).min(-1) by exercise (Exercise: p < 0.01). Lactate oxidation represented 20.6 +/- 1.0% and 17.5 +/- 1.7% of lactate appearance at rest, and 86.3 +/- 3.8% and 86.8 +/- 6.6% during exercise (Exercise: p < 0.01) in GF and C, respectively. Training with GF increased resting lactate appearance and oxidation (Training x Intervention: both p < 0.05), but not during exercise (Training x Intervention: both p > 0.05). Training with GF and C had similar effects to increase lactate clearance during exercise (+ 15.5 +/- 9.2 and + 10.1 +/- 5.9 mL.kg(-1).min(-1); Training: p < 0.01; Training x Intervention: p = 0.97). The findings of this study show that in sedentary participants, glucose-fructose ingestion leads to high systemic lactate appearance, most of which is disposed non-oxidatively at rest and is oxidized during exercise. Training with or without glucose-fructose increases lactate clearance, without altering lactate appearance and oxidation during exercise.