Antibacterial and biological properties of biofunctionalized nanocomposites on titanium for implant application.
JOURNAL OF BIOMATERIALS APPLICATIONS(2016)
摘要
Titanium implants possessing excellent antibacterial activity are highly desirable for the prevention of implant-associated infections. In this study, we demonstrate a simple one-step, water-based procedure for the fabrication of biofunctionalized nanocomposites on titanium for implant application. The formation of biofunctionalized silver nanoparticles with varied biomolecule templates is confirmed by Fourier-transform infrared spectroscopic, contact angle, field-emission scanning electron microscopy, and inductively coupled plasma atomic emission spectrometry analysis. Antibacterial properties of the specimens were determined by challenging them against Staphylococcus aureus. The Ag-incorporated titanium shows excellent antibacterial ability against planktonic bacteria in the suspension and ability to prevent bacterial adhesion. The specimens with optimized biomolecule/silver ratio promote osteoblast differentiation. These biofunctionalized silver nanoparticles-doped titanium specimens, with improved antibacterial activity while maintaining healthy osteoblast cellular activity, have promising application in orthopedics, dentistry, and other biomedical devices.
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关键词
Antibacterial,cytotoxicity,osteoblasts,silver,nanoparticle,titanium
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