Dietary n6/n3 ratio and inflammatory and metabolic profiles of healthy adult C57BL/6 mice

Eating habits changed expressively in the past decades worldwide. Marine sources of n3 fatty acids (FA) intake has declined. Meanwhile, consumption of n6 FA, found in most vegetable oils and associated with a proinflammatory state, rises. Inflammation plays an important role in triggering insulin resistance (IR), a risk factor for different metabolic disorders and proinflammatory cytokines, such as tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) are associated with impaired insulin signaling, thus leading to IR. Hence, alternative sources of n3 FA, such as chia (Salvia hispanica) and rosehip (Rosa rubiginosa) oils, which could improve dietary n6/n3 ratio, may provide health benefits. These seeds are rich in alfa-linolenic FA (ALA), an essential FA that can be bioconverted into the long-chain polyunsaturated FA (LCPUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These LCPUFA attenuate inflammation, improving insulin sensitivity. We aimed to evaluate the effects of different dietar...