An Experimental Study On The Effectiveness Of Hyperbaric Oxygen And Thymoquinone Treatment In Blunt Duedonal Injury

Objective: In duodenum injuries, despite being in a well-preserved area of abdomen, the duodenum is injured due to the presence of behind structures and good fixation lumbar vertebrae. HBO2 treatment reduces ischemia, one of the major causes of secondary damage. HBO2 treatment given serially after trauma, provide clinical, histopathological and biochemical recovery. Thymoquinone(TQ) has been shown to accelerate wound healing in topical or systemic use. We think that Grade 1-2 blunt duodenal traumas will benefit from HBO2 and oral TQ treatment.Methods: 32 Wistar Albino rats were randomly assigned 4 groups. Surgical procedures were applied to rats outside Sham group. The first group was selected as sham, the second group was control, the third group was HBO2 treatment and the fourth group was HBO2 + TQ treatment. The results were examined histopathologically and biochemically in duodenum and serum.Results: Therapy added TQ therapy increased the healing success while HBO2 treatment accelerated healing in histo-pathological findings. Although the parameters studied in the duodenum and serum were partially parallel to histo -pathologic changes, biochemical values were not found statistically significant in generally.Conclusion: In this study, blunt trauma damage was simulated in the 2nd part of the duodenum. HBO2 and TQ treatment improved healing compared to the other groups in Grade 1-2 injuries. We believe that patients with Grade 1 and 2 duodenal injuries, if a successful HBO2 program and a treatment with TQ is added to the conservative therapy will benefit better than the existing treatment methods.