Anthropometric factors and Breslow thickness

Melanoma is the most rapidly increasing cancer form in Norway, and in 2016, 2114 men and women were diagnosed with the disease. This form of cancer is often diagnosed at an early stage, and if you follow changes in your skin you will be able to detect the cancer at an early stage. Melanoma with metastasis (spreading elsewhere in the body), however, is a serious disease that is difficult to treat, and more than 300 people die in Norway from melanoma each year. The thickness of the tumour (called Breslow thickness) is an important factor for survival after melanoma; those with a thin tumour at diagnosis live longer than those with a thick tumour. In a new Norwegian study, researchers explored associations between certain factors (called anthropometric factors ‐ such as body mass index (BMI), body surface area (BSA), height, weight and weight change) and Breslow thickness, overall and by anatomical site and histological subtype (type of melanoma). Nearly 300,000 Norwegian men and women who were enrolled into a study group called the Janus population‐based cohort 1972–2003 were followed for melanoma. By 2014, 2570 cases of melanoma with information on tumour thickness were identified. This large case‐series of incident melanomas, demonstrated positive associations between BMI, BSA, weight and Breslow thickness, and showed that Breslow thickness increased with increasing BMI, BSA and weight, before levelling off or declining at high values, suggesting that behavioural or other mechanisms apply at high values.