Pregnancy rates following in vitro fertilization-embryo transfer (IVF-ET) in women with diminished oocyte reserve who only had one day 3 fresh embryo to transfer

To determine the pregnancy outcome following IVF-ET according to age in women with diminished oocyte reserve (DOR) having only one embryo available to be transferred on day 3. Retrospective review. All IVF-ET cycles in which the female partner had diminished oocyte reserve as evidenced by a day 3 serum follicle stimulating hormone (FSH) >12 mIU/mL and/or a serum anti-mullerian hormone (AMH) level <1 ng/mL, in which there was only a single embryo developing to day 3 to be transferred, were enlisted in the study. The data was stratified according to 5 age groups. Only mild controlled ovarian stimulation was used. Pregnancy rates for patients with diminished ovarian reserve having a single day 3 embryo transferred are seen in the table below.Tabled 1Age<3536-3940-4243-4445-46# transfers165285452295129Average age33.238.241.643.945.9% clinical pregnancy/transfer28.5%18.6%11.7%4.4%3.9%# live delivered41372652% delivered24.8%13.0%5.8%1.7%1.6% Open table in a new tab Women aged 36-39 (average 38.2) with DOR are 52% as likely to have a live baby following a single embryo transfer on day 3 compared to women aged <35 (average 33.2). Women aged 40-42 (average age 41.6) are 23% as likely to conceive as women aged <35 and are 44% as likely to deliver a live baby as women aged 36-39. The younger the age, despite DOR, the greater the chance of reaching a clinical pregnancy (ultrasound evidence of pregnancy at 8 weeks) and the lower the chance of miscarriage in those whose DOR is so severe that there is only one embryo to transfer on day 3. For women aged 43-46 the live delivered pregnancy rates are <2% per transfer, but interestingly they were the same in women aged 45-46 (average 45.9) vs. those 43-44 (average (43.9).