Outcomes Of Elderly Patients Receiving Neoadjuvant Chemoradiation And Adjuvant Chemotherapy For Locally Advanced Rectal Cancer In A Retrospective Cohort

e15145 Background: Data of outcomes of elderly patients ( ≥ 70) with stage II and III rectal cancer treated with multimodal treatment (neoadjuvant chemoradiotherapy, surgery and adjuvant chemotherapy) are limited. Our objective is to evaluate the impact of age on the clinical outcomes in our institution. Methods: Data on170 patients diagnosed from January 2003 to December 2011 with stage II and III rectal adenocarcinoma were collected retrospectively from the Pathology Department data base. 82 patients were ≥ 70 and 11 ≥ 80 years old. Results: Characteristics of patients in terms of staging, ECOG and location of tumor were well balanced between < 70, ≥ 70, ≥ 80. Grade 3 and 4 hematological and non hematological toxicities during chemoradiotherapy were similar in the three groups, as was percentage of pathological complete response (12.5, 12.2 and 9.1% respectively). We observe a non significant trend of more anterior abdominal amputation in elderly (37.5, 43.9 and 54.5%). However, there are clear differences in the percentages receiving adjuvant chemotherapy (86.4, 57.3 and 36.4, p < 0.005). Patients < 70 had a median overall survival (OS) of 114.5 months versus 86.5 in the ≥ 70 cohort (p 0.063) and 59.552 in the ≥ 80 cohort (p 0.056). However these differences disappear between < and ≥ 70 if we examine cancer specific survival (121.8 vs 96.5 m p 0.25) but not with ≥ 80 (64 m p 0.038). Median disease free survival (DFS) is 100.6 m, 68.6 (p 0.033) and 47.6 (p 0.240) respectively. Conclusions: Elderly patients ( ≥ 70) with stage II and III rectal cancer present significantly lower DFS. This could be related with the lower percentage of them receiving adjuvant chemotherapy. This trend is also observed in OS but not confirmed in cancer specific survival except in ≥ 80. Results suggest that we should offer multimodal treatment to elderly people. More studies are needed with this population being sufficiently represented.