Abstract WP361: Sex Differences in Intracerebral Hemorrhage Severity and Mortality

Background and objective: Due to conflicting results in multiple studies, uncertainty remains regarding sex differences in incidence, pathophysiology, and outcome after intracerebral hemorrhage (ICH). We investigated the differential impact of sex on ICH severity and mortality. Methods: We analyzed prospectively collected ICH patients ascertained between 1994 and 2015 at a single tertiary care academic medical center. Clinical variables including past medical history, medications, hemorrhage characteristics, and case-fatality rate at 90 days and one year were assessed. Categorical and continuous characteristics were compared between sexes using chi-square test and t-test, respectively. Multivariable logistic regression was used to examine associations between sex and ICH severity as well as outcome. Results: A total of 2403 patients were investigated: 1292 (53.8 %) male and 1111 female (46.2%). Men with ICH were younger (72 vs. 77 years), had greater smoking and alcohol use, and were more likely to have hypertension, diabetes, hypercholesterolemia and coronary artery disease (all p Conclusions: Sex independently affects early ICH expansion and outcome after ICH, with men experiencing a higher risk of both expansion as well as early and late mortality. Further research is needed to explore the biological mechanisms mediating these observed differences.