IL-17 and IL-22-Secreting Myelin-Specific CD4+ T Cells Corticosteroid Resistant Are Related to Active Brain Lesions in Multiple Sclerosis Patients (P5.345)

Objectives: To evaluate cytokine profile of myelin basic protein (MBP)-specific T-cells from untreated MS patients in early disease phase and correlate it to clinical data and MRI activity. Background: Th1 and Th17 lymphocytes are considered to play central roles in MS. It is possible that their signature cytokines may have distinct roles in MS, and some of them maybe more closely related to disease activity. Methods: Twenty-two patients were selected with recent ( Disclosure: Dr. Dos Santos has received personal compensation for activities with Genzyme. Dr. Hygino has nothing to disclose. Dr. Ferreira has nothing to disclose. Dr. Kasahara has nothing to disclose. Dr. Barros has nothing to disclose. Dr. Sacramento has nothing to disclose. Dr. Andrade has nothing to disclose. Dr. Camargo has nothing to disclose. Dr. Rueda has nothing to disclose. Dr. Alves-Leon has nothing to disclose. Dr. Alvarenga has nothing to disclose. Dr. Bento has nothing to disclose. Dr. Vasconcelos has nothing to disclose.