First-in-human safety and immunogenicity investigations of three adjuvanted reduced dose inactivated poliovirus vaccines (IPV-Al SSI) compared to full dose IPV Vaccine SSI when given as a booster vaccination to adolescents with a history of IPV vaccination at 3, 5, 12 months and 5 years of age

Line M. Lindgren,Pernille N. Tingskov, Annette H. Justesen,Bettina Nedergaard, Klaus J. Olsen,Lars Vibe Andreasen,Ingrid Kromann,Charlotte Sørensen,Jes Dietrich,Birgit Thierry-Carstensen

Vaccine（2017）

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摘要

•Three adjuvanted reduced dose IPV-Al SSI were safe and immunogenic in adolescents.•The three IPV-Al SSI were highly immunogenic, but inferior to IPV Vaccine SSI as a booster.•Reduced dose IPV-Al SSI is intended for markets in need of affordable IPV.

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关键词

Affordable IPV,IPV dose sparing,Dose investigation,Aluminium hydroxide adjuvant

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