Clinical Sequencing In The National Institute Of Health'S Clinical Sequencing Exploratory Research (Cser) Program

To evaluate best uses of and support the integration of genomic sequencing into the clinical workflow, the National Human Genome Research Institute and National Cancer Institute co-fund the Clinical Sequencing Exploratory Research (CSER) project. This initiative aims to 1) leverage NHGRI9s experience in genomic sequencing and analysis to facilitate adoption of these methods into patient care, 2) develop and disseminate best practices for the integration of genomic sequencing into clinical care, and 3) research the ethical, legal, and psychosocial (ELSI) implications of bringing broad genomic data into the clinic. The CSER Consortium includes nine multi-disciplinary projects, nine ELSI-specific projects, a Coordinating Center and NHGRI9s Intramural ClinSeq program. Four of the multi-disciplinary projects and one ELSI project have a specific focus on cancer settings and outcomes: CanSeq (Dana-Farber Cancer Inst.), BASIC3 (Baylor College of Med.), ONCOSEQ (Univ. of Michigan), and NEXT Medicine (Univ. of Washington) are developing robust frameworks for the integration of whole exome sequencing (WXS) in tumor and germline samples. By measuring the effectiveness of novel platforms for returning results, analyzing the costs and benefits of using sequencing technology to identify rare variants, and evaluating patient experiences, these projects will help define best practices for incorporating WXS into cancer management. As of August 2014, these projects had collected WXS data from 415 patients (269 adults and 146 children). The CSER consortium also has nine working groups that strive to advance best practices and communicate lessons learned to the community regarding the use of genomic sequence data in the clinical workflow. The Tumor Working Group explores the unique technical, interpretive, and ethical challenges involved in clinical sequencing of both somatic and germline cancer genomes. This presentation will highlight progress to date, anticipated products and results, and the relationship between these cancer sequencing projects and broader CSER consortium efforts. Citation Format: Catherine Crawford, Charlisse Caga-Anan, Dave Kaufman, Alexander Lee, Jean Mcewen, Sheri Schully, Carolyn Hutter, Lucia Hindorff. Clinical sequencing in the National Institute of Health9s Clinical Sequencing Exploratory Research (CSER) Program. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4888. doi:10.1158/1538-7445.AM2015-4888