P6.13 Ambulatory and Office Central Systolic Blood Pressure is More Closely Associated with Left Ventricular Mass Than Ambulatory and Office Peripheral Systolic Blood Pressure in a Young Normotensive Population

Background High blood pressure (BP) at a young age and increased left ventricular mass (LVM) are associated with increased risk of future cardiovascular mortality. In addition, ambulatory 24-hour central systolic BP (24cSBP) is more closely associated with LVM than either 24-hour peripheral SBP (24pSBP) or office measurements of pSBP and cSBP. However these associations have only been observed in older hypertensive patients. The purpose of this study was to determine (1) if BP was associated with LVM, and (2) which method of BP measurement was more strongly associated with LVM in a young healthy normotensive population. Methods Forty-one adults (23±4yrs, 27% male) took part in the study. LVM was measured using 2-D echocardiography (Vividq, GE) and indexed to body surface area (LVMi). Both office and 24-hour pSBP and cSBP were measured using the Mobil-O-Graph system (IEM, Germany). cSBP’s were calculated using brachial mean and diastolic pressures (MAP-cal). Results Participants had normal office pSBP (117 ±10 mmHg) and LVMi (79 ±17 g/m 2 ) values. On average, office cSBP (128 ±19 mmHg) was significantly higher than 24cSBP (123 ±14 mmHg, P<0.05). LVMi was not associated with pSBP (r = 0.275, P = 0.82) and weakly associated with 24pSBP (r = 0.320, P = 0.041). However the strongest associations with LVMi were with cSBP MAP-cal (r = 0.506, P = 0.001) and 24cSBP MAP-cal (r = 0.556, P<0.0001). Conclusion In the current young normotensive population, both office cSBP and 24cSBP were more closely associated with LVMi than peripheral measures of SBP. These findings may have implications for the progression and potential treatment of hypertension-induced target organ damage.