Synthesis, antimalarial properties and 2D-QSAR studies of novel triazole-quinine conjugates

Hassan M. Faidallah,Siva S. Panda,Juan C. Serrano,Adel S. Girgis,Khalid A. Khan,Khalid A. Alamry, Tanya Therathanakorn,Marvin J. Meyers,Francis M. Sverdrup,Christopher S. Eickhoff,Stephen G. Getchell,Alan R. Katritzky

Bioorganic & Medicinal Chemistry（2016）

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摘要

•Designed and synthesized a set of triazole containing quinine conjugates.•Synthesized conjugates shows promising antimalarial activity.•2D-QSAR studies supports the biological data.•Developed QSAR model could be useful tool for new drug development.

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关键词

Antimalarial,Quinine,Triazole,Click chemistry,QSAR

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