From nano to micro, and back: porphyrin-based cancer theranostics

Event Abstract Back to Event From nano to micro, and back: porphyrin-based cancer theranostics Gang Zheng1 1 University of Toronto, Department of Medical Biophysics, Canada Porphysomes, self-assembled from porphyrin-lipid building blocks, are unique organic nanoparticles with intrinsic multimodal photonic properties. The high-density packing of porphyrin bilayers enables these nanoparticles to absorb and convert light energy to heat with extremely high efficiency, making them ideal candidates for photothermal therapy and photoacoustic imaging. Upon nanostructure disruption, fluorescence and photoreactivity of free porphyrins are restored to enable low background fluorescence imaging and activatable photodynamic therapy. Moreover, metal ions can be directly incorporated into the porphyrin building blocks thus unlocking porphysomes’ potential for PET and MRI, making them a true “one-for-all” nanoplatform ideally suited for personalized photomedicine. We have validated porphysomes’ multimodal theranostic utilities in different cancer types (prostate, ovarian, head & neck, pancreatic and brain cancer), tumor models (subcutaneous, orthotopic, chemically-induced and primary) and animal species (mice, hamsters and rabbits). By changing the way porphyrin-lipid assembles, we also developed porphyrin lipoprotein nanoparticles (~20nm) and porphyrin shell microbubbles (~2um), further broadening the utilities of porphyrin-based cancer theranostics. In particular, we discovered that porphyrin microbubbles could be converted in situ by ultrasound into nanoparticles and visualized optically within tumor. Bursting the microbubbles with ultrasound would increase the permeability of the vasculature, while forming and delivering porphyrin nanoparticles to the tumor, then used for imaging or therapy. Therefore, there is no dependence on the enhanced permeability and retention effect to deliver the nanoparticle. By closing the nano-micro-nano loop, the simple yet intrinsic multimodal nature of porphyrin-based cancer theranostics represents a new frontier for cancer imaging and therapy. Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: New Frontier Oral Topic: Personalized medicine and biomaterials Citation: Zheng G (2016). From nano to micro, and back: porphyrin-based cancer theranostics. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.02390 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Gang Zheng Google Gang Zheng Google Scholar Gang Zheng PubMed Gang Zheng Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.