Allergenicity reduction of cow’s milk proteins using latex peptidases

•Latex peptidases were able to perform total hydrolysis of caseins.•On the other hand, whey proteins were more resistant to proteolysis.•Heat pretreatment of the whey proteins enhanced the degree of hydrolysis.•In vivo tests showed that latex peptidases reduced antigenicity and allergenicity.•Results were similar to a commercial partially hydrolyzed formula.