Greater Curvature Plication with Duodenal–Jejunal Bypass: a Novel Metabolic Surgery for Type 2 Diabetes Mellitus

Objective The study investigated the use of great curvature plication with duodenal–jejunal bypass (GCP-DJB) in a type 2 diabetic with obesity rat model. Methods Twenty-two Sprague-Dawley rats were given a high fat and sugar diet with subsequent intraperitoneal injection of a small dosage of streptozotocin (30 mg/kg) and randomly assigned to either GCP-DJB ( n = 12) or Sham surgery ( n = 10). Body weight, peripheral blood glucose, and fasting serum insulin were assayed, and insulin resistance index (IRI) was calculated, before and at 1, 2, 4, and 8 weeks after surgery. Results No differences were found in the preoperative characteristics of the two groups ( P > 0.05). At week 1, the body weights decreased significantly, but there was no significant difference between the two groups ( P > 0.05).The fasting blood glucose was significantly lower in the GCP-DJB than in the Sham group ( P < 0.05), serum insulin levels were higher ( P < 0.05), and IRI began to decline ( P < 0.05). From 2 to 8 weeks, the body weight of Sham group gradually recovered and continued to rise, while the GCP-DJB group remained at a relatively lower state. Compared to the Sham group, the body weight, fasting blood glucose as well as IRI of GCP-DJB rats had significantly decreased ( P < 0.05). But, the fasting insulin concentrations had significantly increased ( P < 0.05). Conclusion This novel GCP-DJB procedure established a stable animal model for the study of metabolic surgery to treat type 2 diabetes mellitus (T2DM).