A Phase 1 dose escalating study of double mutant heat-labile toxin LTR192G/L211A (dmLT) from Enterotoxigenic Escherichia coli (ETEC) by sublingual or oral immunization.

David I Bernstein,Marcela F Pasetti,Rebecca Brady,Amanda D Buskirk,Rezwanul Wahid,Michelle Dickey,Mitchell Cohen,Holly Baughman,Jill El-Khorazaty,Nicole Maier,Marcelo B Sztein,Shahida Baqar,A Louis Bourgeois

Vaccine（2019）

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摘要

•This dose escalating clinical trial showed that the dmLT formulation was safe.•The formulation was only moderately immunogenic at doses up to 50 µg.•Antibody titers following oral administration were higher than after SL dosing.

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关键词

ETEC,Escherichia coli,Vaccine,Sublingual,Oral,dmLT

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